Question: Describe the most appropriate study design for each scenario below. (Optional: there may be more than one answer, so provide a brief justification for partial credit.):

1. An unusual clinical presentation of a disease or condition.
2. Determine whether cases of the birth defect microcephaly are associated with infection with the Zika virus within a relatively short time window.
3. Determining whether 9/11 first responders have an increased risk of cancers or pulmonary diseases.
4. Weighing the evidence to determine whether there is a relationship between have periodontitis (gum disease) and coronary heart disease.
5. Whether a mobile phone application can improve medication adherence.
6. Testing two or more real-world treatments in a clinical setting.

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