Question:

One method for assessing the bioavailability of a drug is to note its concentration in blood and/or urine samples at certain periods of time after giving the drug. Suppose we want to compare the concentrations of two types of aspirin (types A and B) in urine specimens taken from the same person, 1 hour after he or she has taken the drug. Hence, a specific dosage of either type A or type B aspirin is given at one tiMeand the 1-hour urine concentration is measured. One week later, after the first aspirin has presumably been cleared from the system, the same dosage of the other aspirin is given to the same person and the 1-hour urine concentration is noted. Because the order of giving the drugs may affect the results, a table of random numbers is used to decide which of the two types of aspirin to give first.

This experiment is performed on 10 people; the results are given in the following table.

a) What are the appropriate hypotheses?

b) Perform an appropriate parametric statistical procedure to test these hypotheses and briefly explain your results (? level = 0.05).

c) Perform an appropriate non-parametric statistical procedure to test these hypotheses and briefly explain your results (? level = 0.05).

d) Compare your results in parts b) and c), and discuss which method you feel is more appropriate here.