Question: After the pilot study described in problem 6 the main trial is conducted and involves a total of 200 patients. Patients are enrolled and randomized to receive either the experimental medication or the placebo. The data shown below are data collected at the end of the study after 6 weeks on the assigned treatment. Generate a 95% confidence interval for the difference in proportions of patients with hypertension between groups.

Experimental Placebo

(n=100) (n=100)

% Hypertensive 14 22