. This data was provided by Drs. Pan and Chi in the Department of Imaging Physics of UT MD Anderson Cancer


Problem 1 . This data was provided by Drs. Pan and Chi in the Department of Imaging Physics of UT MD Anderson Cancer Center. Please contact them if you wish to use the data. The data consists of measurements of the tumor sizes of over 200 different patient tumors. The tumor sizes were computed by two different methods and each line of data has the different measurements from a single tumor. For this study it was important that the methods did not differ at the = .01 level. As always, I want to see:

  1. What is the question that you are trying to answer?
  2. What are the null and alternative hypotheses?
  3. What method will you use to test the hypotheses and what assumptions do you make in using this method?
  4. What is the test statistic?
  5. What is the rejection region?
  6. What is the calculation procedure? Since I expect you to use a computer, give me enough information that I could reproduce your procedure.
  7. State a conclusion?
Tumor volumes
PET-AVG PET-HCT
111.41 109.99
2.05 0.64
3.42 3.52
4.55 4.25
3.67 4.69
9.05 4.89
5.67 5.04
7.38 6.90
6.80 6.95
9.58 9.39
15.79 15.31
16.15 16.54
22.84 24.45
49.93 41.76
68.75 67.28
252.85 246.25
1.47 0.44
0.88 0.49
1.13 0.78
1.47 1.27
3.13 2.30
7.48 4.50
5.04 4.60
1.08 0.29
0.68 0.68
1.52 1.42
1.52 1.52
3.42 2.89
8.17 3.13
2.74 3.28
5.48 4.01
5.57 5.97
6.21 6.41
14.28 8.46
11.83 11.88
15.35 12.08
29.58 27.97
33.15 29.00
45.77 43.52
62.51 60.50
87.83 84.21
101.81 96.62
349.66 346.77
0.59 0.29
0.93 0.54
0.59 0.59
1.81 0.69
0.69 0.74
1.03 0.98
1.13 1.13
2.01 1.42
1.71 1.47
2.01 1.61
2.59 1.66
2.79 1.96
2.10 2.00
2.45 2.74
2.64 2.79
3.47 2.98
4.21 3.28
3.91 3.72
4.85 4.50
4.30 5.00
6.21 5.77
5.82 5.77
7.14 6.02
9.54 7.78
9.44 10.81
17.07 14.08
21.12 17.95
21.03 20.83
31.15 26.41
45.08 45.67
70.38 67.25
136.67 131.83
0.59 0.44
0.93 0.54
0.68 0.59
0.78 0.83
1.61 1.61
4.65 3.38
3.47 3.42
4.69 5.43
5.82 6.06
7.39 7.93
6.21 9.44
32.91 29.09
29.00 30.37
1.81 0.39
1.96 0.64
0.78 1.03
1.32 1.22
1.52 1.47
1.81 1.76
2.64 1.96
2.01 2.45
2.40 2.69
4.50 4.60
4.06 4.74
9.16 7.00
8.56 8.46
14.47 13.98
24.36 24.51
39.75 37.21
81.20 75.29
0.29 0.49
0.78 0.73
5.09 4.89
7.48 7.04
87.19 92.91
0.29 0.24
0.98 0.93
1.22 1.08
1.81 1.86
2.11 1.86
4.16 2.10
2.49 2.64
2.79 2.69
3.03 3.23
4.89 3.42
3.86 3.57
5.92 7.09
7.68 8.61
11.54 8.85
20.15 11.54
13.31 11.84
20.83 19.81
31.98 30.81
209.78 187.63
279.08 269.69
470.52 448.71
0.68 0.64
0.73 0.69
0.54 0.69
0.78 0.83
1.03 0.88
5.77 1.56
2.93 1.61
3.48 2.55
3.91 2.79
5.23 3.13
4.74 3.62
4.40 3.77
7.77 6.36
9.93 8.07
10.32 10.81
11.54 14.33
25.97 23.72
30.12 27.29
124.87 120.13
179.27 159.66
2.05 0.10
0.64 0.83
9.73 1.86
3.42 2.25
11.54 8.85
11.49 10.42
11.78 10.90
10.02 12.47
10.22 12.91
15.99 13.94
17.76 15.75
25.97 26.94
33.25 30.46
165.86 172.07
3.18 1.42
4.69 4.40
9.98 8.61
11.30 10.66
23.24 16.79
49.47 47.61
67.78 61.13
123.93 116.06
1.03 0.93
1.32 1.37
3.96 1.86
3.23 2.54
7.78 4.70
13.10 10.56
50.67 23.97
45.70 40.10
109.34 107.53
1.66 0.20
1.27 0.29
2.89 0.73
1.76 2.49
37.95 33.40
148.76 129.25
0.44 0.24
1.22 0.39
2.45 0.59
6.11 4.74
11.69 11.59
22.59 20.49
27.87 27.09
85.77 85.62
169.78 160.73
3.62 2.79
83.77 88.08
6.65 5.62
95.55 85.38
1.03 1.27
74.41 75.29
1.32 0.78
0.73 0.15
20.34 17.07
181.10 183.80

Problem 2 . A common problem in medical physics is to measure the radiation dose to a specific point. For many purposes the preferred method is to expose film to a series of standardized radiation dosages which are determined using a different detector. The optical density of the film provides a curve that can be fitted to the standard dosages and in practice the optical density is measured and a radiation dosage calculated from the fitted curve. Data for this procedure is provided in a spread sheet provided by Dr. David Followill and Scott Davidson. You are to do a regression of optical density versus dose using multivariate regression model of the form:

\[OD(D)={{\beta }_{0}}+{{\beta }_{1}}D+{{\beta }_{2}}{{D}^{2}}+{{\beta }_{3}}{{D}^{3}}\]

where OD is the optical density at a dose level D. The parameters 0 , … 3 are the regression coefficients of the dose raised to the 0, 1,2 and 3 rd power. The question is what power do you need to fit the data to a curve. More generally, how much better is a third order than a second order fit? Prepare a table showing a goodness of fit values for the different degrees of polynomials.

Hint: This is actually a linear regression problem in the values of i . with the D i each being a predictor variable. I realize that you will need to do some exploring to discover how to do these calculations, but it is a common type of problem.

Lot no. EBT 47171-01I
Run 1 Run 2 Run 3
film no OD film no OD film no OD Dose (cGy)
37 0.14 38 0.141 39 0.141 0
1 0.268 13 0.262 25 0.26 31
2 0.351 14 0.348 26 0.346 61
3 0.434 15 0.434 27 0.431 103
4 0.545 16 0.546 28 0.543 180
5 0.651 17 0.653 29 0.65 293
6 0.729 18 0.73 30 0.727 411
7 0.77 19 0.769 31 0.769 513
8 0.822 20 0.82 32 0.817 616
9 0.861 21 0.862 33 0.853 719
10 0.895 22 0.892 34 0.885 822
11 0.919 23 0.913 35 0.91 924

Problem 3 : A study was conducted to investigate drinking problems among college students. In 1983 a group of students were asked whether they had ever driven an automobile while drinking.

(At this time the legal drinking age was 18.) Four years later a similar study, after the drinking age was raised, was undertaken and the results for both studies are presented below:

Drove while drinking Year Year Totals
1983 1987
Yes 1250 991 2241
No 1387 1666 3053
Total 2637 2657 5294
  1. Use the chi-square test to evaluate the null hypothesis that the proportions of students driving while drinking are the same in two calendar years.
  2. Test the hypothesis that the proportions of students driving while drinking was the same in the two years.
  3. Construct a 95% confidence interval for the true difference in population proportions.

Problem 4 . In Problem 4 researchers have measured radiation dosages,(mGy), to a range of sites in phantom (on an imitation 5 year old doll). There were 5 different protocols for irradiation using a CT scan and each different scan was measured at a series of different organs: Brain, left eye, right eye, head thyroid (dose received by the thyroid when scanning the head), chest thyroid (dose to thyroid when scanning the chest), sternum, left and right breasts and left and right lungs.

Assume that we do not have to consider interactions between different sites and protocols so that we can avoid doing a two-way analysis. But we do want to answer the following questions:

  1. Using the different groups, is there a difference between groups assuming protocols are the same?
  2. Assuming results at different sites can be treated the same, is there a difference in results for different protocols?
dose
# protocol organ mGy
1 axial brain 63.65746
2 axial brain 32.25414
3 axial brain 32.33149
4 axial brain 32.65055
5 axial brain 32.51519
6 axial brain 23.25
7 hel 0.516 brain 30.15708
8 hel 0.516 brain 31.12024
9 hel 0.516 brain 31.07354
10 hel 0.516 brain 30.7588
11 hel 0.516 brain 30.47006
12 hel 0.516 brain 28.71
13 hel 0.984 brain 31.65382
14 hel 0.984 brain 31.95048
15 hel 0.984 brain 31.22714
16 hel 0.984 brain 32.12614
17 hel 0.984 brain 31.10852
18 hel 0.984 brain 27.92
19 axial left eye 68.05663
20 axial left eye 33.74309
21 axial left eye 34.70028
22 axial left eye 34.64227
23 axial left eye 34.30387
24 axial left eye 18.14
25 hel 0.516 left eye 33.08838
26 hel 0.516 left eye 33.00144
27 hel 0.516 left eye 32.99111
28 hel 0.516 left eye 28.1293
29 hel 0.516 left eye 33.98833
30 hel 0.516 left eye 25.06
31 hel 0.984 left eye 32.97956
32 hel 0.984 left eye 28.8699
33 hel 0.984 left eye 33.03506
34 hel 0.984 left eye 28.36924
35 hel 0.984 left eye 27.64502
36 hel 0.984 left eye 21.55
37 axial right eye 69.33287
38 axial right eye 35.13536
39 axial right eye 34.79696
40 axial right eye 35.09669
41 axial right eye 35.14503
42 axial right eye 19.06
43 hel 0.516 right eye 30.3153
44 hel 0.516 right eye 33.93292
45 hel 0.516 right eye 30.30073
46 hel 0.516 right eye 32.72636
47 hel 0.516 right eye 35.15538
48 hel 0.516 right eye 23.71
49 hel 0.984 right eye 34.17699
50 hel 0.984 right eye 32.25488
51 hel 0.984 right eye 34.26212
52 hel 0.984 right eye 32.42364
53 hel 0.984 right eye 32.7796
54 hel 0.984 right eye 26.18
55 axial head thyroid 88.76657
56 axial head thyroid 49.13536
57 axial head thyroid 47.78177
58 axial head thyroid 43.00552
59 axial head thyroid 44.05939
60 axial head thyroid 39.51
61 hel 0.516 head thyroid 42.08172
62 hel 0.516 head thyroid 40.69813
63 hel 0.516 head thyroid 42.19909
64 hel 0.516 head thyroid 40.37805
65 hel 0.516 head thyroid 41.71964
66 hel 0.516 head thyroid 41.87
67 hel 0.984 head thyroid 41.60521
68 hel 0.984 head thyroid 40.3832
69 hel 0.984 head thyroid 41.20996
70 hel 0.984 head thyroid 41.34238
71 hel 0.984 head thyroid 41.61828
72 hel 0.984 head thyroid 37.96
73 axial chest thyroid 49.78903
74 axial chest thyroid 50.31312
75 axial chest thyroid 50.83722
76 axial chest thyroid 49.89385
77 axial chest thyroid 50.31312
78 axial chest thyroid 27.95
79 hel 0.516 chest thyroid 38.70304
80 hel 0.516 chest thyroid 38.39365
81 hel 0.516 chest thyroid 38.66436
82 hel 0.516 chest thyroid 38.09392
83 hel 0.516 chest thyroid 40.42403
84 hel 0.516 chest thyroid 26.7
85 hel 0.984 chest thyroid 40.70442
86 hel 0.984 chest thyroid 40.67541
87 hel 0.984 chest thyroid 39.96961
88 hel 0.984 chest thyroid 39.66022
89 hel 0.984 chest thyroid 39.93094
90 hel 0.984 chest thyroid 28.80
91 hel 1.375 chest thyroid 41.87431
92 hel 1.375 chest thyroid 41.90331
93 hel 1.375 chest thyroid 42.29972
94 hel 1.375 chest thyroid 41.75829
95 hel 1.375 chest thyroid 42.03867
96 hel 1.375 chest thyroid 27.36
97 axial sternum 50.78486
98 axial sternum 51.2037
99 axial sternum 51.51784
100 axial sternum 52.1461
101 axial sternum 51.83197
102 axial sternum 22.29
103 hel 0.516 sternum 39.3605
104 hel 0.516 sternum 39.93094
105 hel 0.516 sternum 40.23066
106 hel 0.516 sternum 39.28315
107 hel 0.516 sternum 39.80525
108 hel 0.516 sternum 27.55
109 hel 0.984 sternum 39.19613
110 hel 0.984 sternum 40.66575
111 hel 0.984 sternum 40.11464
112 hel 0.984 sternum 39.42818
113 hel 0.984 sternum 38.00691
114 hel 0.984 sternum 29.75
115 hel 1.375 sternum 49.46409
116 hel 1.375 sternum 32.0221
117 hel 1.375 sternum 48.51657
118 hel 1.375 sternum 48.87431
119 hel 1.375 sternum 46.70856
120 hel 1.375 sternum 33.58
121 axial left breast 49.05529
122 axial left breast 49.89385
123 axial left breast 49.89385
124 axial left breast 49.68421
125 axial left breast 48.95047
126 axial left breast 19.43
127 hel 0.516 left breast 37.38812
128 hel 0.516 left breast 38.82873
129 hel 0.516 left breast 38.75138
130 hel 0.516 left breast 39.08978
131 hel 0.516 left breast 36.25691
132 hel 0.516 left breast 25.39
133 hel 0.984 left breast 38.52901
134 hel 0.984 left breast 40.07597
135 hel 0.984 left breast 40.04696
136 hel 0.984 left breast 40.20166
137 hel 0.984 left breast 39.86326
138 hel 0.984 left breast 28.54
139 hel 1.375 left breast 32.06077
140 hel 1.375 left breast 46.97928
141 hel 1.375 left breast 46.73757
142 hel 1.375 left breast 46.96961
143 hel 1.375 left breast 45.97376
144 hel 1.375 left breast 19.9
145 axial right breast 50.41794
146 axial right breast 51.04685
147 axial right breast 50.7324
148 axial right breast 49.68421
149 axial right breast 49.68421
150 axial right breast 25.99
151 hel 0.516 right breast 38.80939
152 hel 0.516 right breast 37.23343
153 hel 0.516 right breast 37.75552
154 hel 0.516 right breast 36.43094
155 hel 0.516 right breast 38.47099
156 hel 0.516 right breast 31.48
157 hel 0.984 right breast 37.39779
158 hel 0.984 right breast 38.94475
159 hel 0.984 right breast 38.06492
160 hel 0.984 right breast 39.3895
161 hel 0.984 right breast 36.78867
162 hel 0.984 right breast 30.11
163 hel 1.375 right breast 46.95994
164 hel 1.375 right breast 31.57735
165 hel 1.375 right breast 45.03591
166 hel 1.375 right breast 45.69337
167 hel 1.375 right breast 45.41298
168 hel 1.375 right breast 36.42
169 axial left lung 38.46857
170 axial left lung 36.26737
171 axial left lung 35.74328
172 axial left lung 38.0493
173 axial left lung 38.15412
174 axial left lung 27.58
175 hel 0.516 left lung 31.15193
176 hel 0.516 left lung 30.05939
177 hel 0.516 left lung 29.80801
178 hel 0.516 left lung 30.7942
179 hel 0.516 left lung
180 hel 0.516 left lung 31.81
181 hel 0.984 left lung 31.98343
182 hel 0.984 left lung 33.54006
183 hel 0.984 left lung 33.68508
184 hel 0.984 left lung 33.64641
185 hel 0.984 left lung 30.38812
186 hel 0.984 left lung 31.97
187 hel 1.375 left lung 36.18923
188 hel 1.375 left lung 35.77348
189 hel 1.375 left lung 33.54972
190 hel 1.375 left lung 32.89227
191 hel 1.375 left lung 33.42403
192 hel 1.375 left lung 34.57
193 axial right lung 39.97285
194 axial right lung 40.70726
195 axial right lung 41.12692
196 axial right lung 41.12692
197 axial right lung 40.39251
198 axial right lung 26.01
199 hel 0.516 right lung 31.46133
200 hel 0.516 right lung 30.72652
201 hel 0.516 right lung 31.14227
202 hel 0.516 right lung 31.09392
203 hel 0.516 right lung 32.31215
204 hel 0.516 right lung 30.32
205 hel 0.984 right lung 31.62569
206 hel 0.984 right lung 30.37845
207 hel 0.984 right lung 30.85221
208 hel 0.984 right lung 30.18508
209 hel 0.984 right lung 31.58702
210 hel 0.984 right lung 27.05
211 hel 1.375 right lung 34.99033
212 hel 1.375 right lung 31.75138
213 hel 1.375 right lung 36.0732
214 hel 1.375 right lung 34.91298
215 hel 1.375 right lung 34.73895
216 hel 1.375 right lung 36.89

Problem 5 . A study in Italy compared the treatment of women with breast cancer by different specialties. There possible treatments for radical surgery regardless of age (R), conservative surgery only for younger patients (CR) and conservative surgery regardless of age (C). The results were:

Specialty R CR C Total
Internal 6 22 42 70
Surgery 23 61 127 211
Radiotherapy 2 3 54 59
Oncology 1 12 43 56
Gynecology 1 12 31 44
Total 33 110 297 440
  1. At the .05 level of significance, test the null hypothesis that there is no association between physician specialty and recommended treatment
  2. What do you conclude?
Price: $34.93
Solution: The downloadable solution consists of 21 pages, 1393 words and 19 charts.
Deliverable: Word Document


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