Question: Tourette's SyndroMeand Nicotine Gum

McConville et al. report the effects of chewing one piece of nicotine gum (containing 2 mg of nicotine) on tic frequency in patients whose Tourette's disorder was inadequately controlled by haloperidol. In the study, the number of tics in a 30 minute period was measured at baseline and then each patient was given a piece of nicotine gum. The number of tics observed for the 30 minutes while they were chewing the gum was recorded and then for the two consecutive half hour periods after they spit out the gum.

After eliminating patient effects, can we conclude that the mean number of tics differs among the four conditions? These data are in the file Tourettes.JMP. (6 pts.)

The variables in the data file are:

? Patient – patient ID number

? Time Period –

1 - Base (baseline)

2 - Gum Chew (while chewing gum)

3 - 0 – 30 min (0 – 30 minutes after chewing gum)

4 - 30 – 60 min (30 – 60 minutes after chewing gum)

* Note: Each time period was 30 minutes in length

? Tics/30 min – number of tics during the 30 minute period (response)

a) Conduct an appropriate test to determine if the mean number of tics per 30 minute period is related to the four conditions. Summarize your findings. (4 pts.)

b) Use an appropriate multiple comparison procedure to compare the mean number of tics per 30 minutes across the different time periods. Also examine CI’s for the differences in means. Summarize your findings. (4 pts.)