Question: Does the herb Saint-John's-wort relieve major depression? Here are some excerpts from the report of a study of this issue. The study concluded that the herb is no more effective than a placebo.

1. "Design: Randomized, double-blind, placebo-controlled clinical trial ...." Explain the meaning of each of the terms in this description.
2. "Participants ... were randomly assigned to receive either Saint-John's wort extract \((n=98)\) or placebo \((n=102) \ldots\) The primary outcome measure was the rate of change in the Hamilton Rating Scale for Depression over the treatment period." Based on this information, use a diagram to outline the design of this clinical trial.

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