[Solution] The following is an exerpt from Phytomedicine 2008 Jun;15(6-7):400-7. 2008 Jan 28. Boswellic acids: A leukotriene inhibitor also effective through


Question: The following is an exerpt from Phytomedicine 2008 Jun;15(6-7):400-7. 2008 Jan 28. Boswellic acids: A leukotriene inhibitor also effective through topical application in inflammatory disorders:

"Boswellic acids (BA), a natural mixture isolated from oleo gum resin of Boswellia serrata comprised of four major pentacyclic triterpene acids: beta-boswellic acid (the most abundant), 3-acteyl-beta-boswellic acid, 11-keto-beta-boswellic acid, and 3-acetyl-11-keto-beta-boswellic acid, is reported to be effective as anti-inflammatory, immunomodulatory, anti-tumor, anti-asthmatic and in Crohn's disease. It inhibits pro-inflammatory mediators in the body, specifically leukotrienes via inhibition of 5-lipoxygenase, the key enzyme of leukotriene synthesis, is the scientifically proved mechanism for its anti-inflammatory/anti-arthritic activity"

In an experiment, a researcher randomly assigns previously diagnosed asthmatic subjects into one of four groups: Placebo, 450mg dose, 900mg dose, 1350mg dose.

This study proceeds for approximately 6 months. At the end of six months, each subject donates a vial of blood and has their plasma levels of leukotrienB4 measured using chromatographic fractionation and radioimmunoassay. The results are shown below. All concentrations are in pg/ml:

Placebo 450 mg 900mg 1350 mg
36 43 51 26
44 39 43 36
38 52 43 28
55 44 33 27
38 45 36 44
45 35 42 38
49 38 38 36

Using your roadmap, test the appropriate hypothesis and report your findings in APA format

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