Epilepsy Drug

A study was conducted to demonstrate the effectiveness of an investigational drug product in reducing the number of epileptic seizures in patients who have not been helped by standard therapy. Thirty patients participated in the study, with 15 randomized to the drug treatment group and 15 to the placebo group. The data are available in a file called seizures.sav .

Analyze these data as a repeated measures design, with measurements at 6 time periods.

1. Plot mean number of seizures over time, indicating drug group. Does the drug appear to be effective in reducing number of seizures? What about the graph tells you this?
   
   
2. Perform the analysis of variance and test for interaction, drug, and time effects. State your conclusions.
   
   
3. Compare the drug and the placebo at each of the 6 time periods. To do this, refer to slides 32 –38 of the set of slides titled "Repeated Measures Part 2". Select "Options" and move the interaction term, only, to the "Display means for" box. Then paste the syntax. You will see a line that says
   
   /EMMEANS = TABLES(drug*time)
   (supposing that you named your variables "drug" and "time"). Add to this
   COMPARE(drug)
   At what time periods do the results differ for the drug and the placebo groups?
4. Using the same technique as in part (3), compare the time periods for each drug. For the placebo group, in which weeks are responses different? For the drug group, in which weeks do the responses differ?

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Solution: The downloadable solution consists of 8 pages, 372 words and 3 charts.
Deliverable: Word Document